Can we reduce the ANA level?

High ANA titers - what does this mean?

Of course, a remote diagnosis or individual advice is neither possible nor permitted.

But what you can say in general about the questions:

To 1: There are ANAs, even without a disease behind them. The probability that ~ Dnur ~ S is a laboratory value of no further importance decreases with the level of the value. Values ​​of 1:40 are generally considered to be completely unproblematic and still within the normal biological range of variation; this also applies (depending on the method used) for values ​​of 1:80 and, with restrictions, also for 1: 160 when using Hep-2 cells). However, if high ANA values, e.g. with titers above 1: 1,280 or 1: 2,560 or even higher, are associated with symptoms, especially if these themselves suggest the possibility of an autoimmune disease or a related problem, such as joint pain, general decreased performance, exhaustion, skin bleeding, neurological symptoms, amenorrhea, they are more likely than a so-called epiphenomenon or a laboratory value or whatever you want to call it, but probably have a diagnostic meaning, whereby one stops at ANAs first always have to think about the possibility of an autoimmune disease or autoimmune reaction of whatever kind (the latter includes the possibility of autoimmune reactions as a result of an infection with so-called lymphotropic viruses such as EBV = Epstein-Barr virus; it is thought of far too seldom!).

To 2: results from the answer to question 1.

To 3: ANAs can occur in a number of autoimmune diseases. Pathognomonic = trend-setting for diseases from the group of collagenoses including systemic lupus erythematosus (SLE), scleroderma and the related CREST syndrome as well as less common diseases such as Jo-1 antibody syndrome. From the group of diseases that otherwise fall into rheumatology and immunology, there are also ANAs relatively frequently in chronic polyarthritis (rheumatoid arthritis), especially if it has a strong ~ dautoimmune ~ S character and already has a tendency to overlap with the collagenoses shows, still with some vasculitides, which are more likely to be characterized by ANCA's. In the area of ​​gastroenterology, ANAs can be seen in inflammatory bowel diseases, especially Crohn's disease, and in autoimmune diseases of the liver (autoimmune hepatitis, some of which are also referred to as ~ dlupoids ~ S hepatitis in analogy to systemic lupus erythematosus). In endocrinology, ANAs are seen primarily in connection with autoimmune diseases of the thyroid gland (~ DAutoimmune thyreopathies ~ S). It is not so well known that ANAs can also develop in a number of infectious diseases. Particularly noteworthy are infections with so-called lymphotropic pathogens, in particular with Epstein-Barr virus (EBV), human herpes virus 6 (HHV-6) and cytomegaly virus (CMV), and also in chronic hepatitis B and C. This does then the differentiation from autoimmune hepatitis is sometimes a bit difficult.